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KMID : 0363620210420020021
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Journal of Korean Oriental Medicine
2021 Volume.42 No. 2 p.21 ~ p.30
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Anti-inflammatory Effects of Ojeok-san in LPS-induced Inflammatory Rat Model
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Kim Joo-Hee
Lee Dong-Hyuk
Kim Ji-Hye
Jung Sung-Eun
Ham Seong-Ho
Yang Woong-Mo
Kwon Bo-In
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Abstract
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Objectives: The aim of this study is to investigate the anti-inflammatory effects of Ojeok-san and compare the therapeutic effects according to its formation.
Methods: We evaluated the anti-inflammatory effects of Ojeok-san using lipopolysaccharide (LPS) induced inflammatory animal model. Male SD rats were administered intra-orally with two different formulation types of Ojeok-san according to prescribed dosage. One hour later, to induce inflammatory responses, subsequent intra-peritoneal injection of LPS was conducted. After 5 hours later, serum TNF-α, IL-1β, IL-6 and PGE2 levels were measured by ELISA to assess the alteration of pro-inflammatory markers.
Results: In our experiment, regardless of its formation, administration of Ojeok-san decreased TNF-α, IL-1β, IL-6 and PGE2 level in serum. Furthermore, LPS-induced toxicity of liver and kidney was not detected by Ojeok-san administration.
Conclusions: The anti-inflammatory effect of Ojeok-san was shown in LPS-induced inflammatory model by decreasing pro-inflammatory markers, and there would be no significant difference in therapeutic effect between two formulation types of Ojeok-san.
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KEYWORD
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Ojeok-san, lipopolysaccharide(LPS)-induced model, anti-inflammatory effect, pro-inflammatory markers
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